Phenylephrine. Chemical structure: –
Phenylephrine contain
2 oxygen marked withe red color 1 nitrogen marked with blue color 1 ring structure contain double bonds 1 hain.
Also HCL. Available generic and
trade names. Generic names: ·
Phenylephrine.·
Metaoxedrin.·
Metasympatol.·
Mezaton.·
Neo-Synephrine.·
Neosynephrine.·
Phenylephrine Hydrochloride.·
Phenylephrine Tannate.·
Tannate, Phenylephrine.Brand names:·
Agrus·
Alcold Plus·
Alercy AX·
Alerid D·
Cezor -Plus·
Cotuss·
Domvent -DMR·
Dxplus·
Fenoride Dx·
Deletus P Available doses and dosage forms. Phenylephrine is mostly
used fornasal congestion, and also may
be used useful in increase B.P. Adult dose to increase B.P :- Intra muscular
or or subcutaneous: 2 to 5 mg every 1
to 2 hours as required.Intra V :100 to 180 mcg/
per min. Usual dose for Nasal Congestion:- ·
10 to 20 mg orally dose every 4 hours as needed. (Liq.)·
10 mg orally every 4 to 6 hoursa day. (10mg tablet)·
10 to 20 mg dose orally twice a day. (chewable for
kida and old ppl)·
2 years to 5 years: 1.7 mL orally dose every 6 doses daily.·
6 years to 11 years: 2.4 to 5 mL orally dosage 2 times a day .· 6 years to 11 years: 10 mL orally 6 times a day. Mechanism of action. First of all Phenylephrine
hydrochloride is an Alpha-1 adrenergic receptor agonist it can activates Alpha-1and Alpha-2 adrenergic receptors. Phenylephrine
administered injection of phenylephrine hydrochloride, increases in the total
blood pressure (sy Bp and Dy BP) because it work on alpha o beta receptors as
agonist so its stimulate them for an action. In conclusion it increase the
blood presser and have other uses. Medical uses. Phenylephrine is a usefully vasoconstrictor. It is used to increase
B.P and nasal decongestant. Its Alpha,1 agonist so its stimulator the
post synapse and make an action , depending on how its administered it makes an
different effects like used for nose or used for B.p intravascular or nasal it
also increases coronary blood flow . increase the pulmonary pressure . can also
use locally for mydriatic action.Side effects. Common side effects:·
redness under your skin·
Irregular
Sleep like insomnia ·
Skin rash or itching·
Loss of appetite· Difficulty breathing·
Fast HR·
Face swelling ·
Allergic action Also this drug may lead to dizziness . Old ppl maybe more effected by this side effects Contraindications · Increase in stomach acid.· High B.P.· Sever or uncontrolled high B.p.· Allergic attach on the drug material
· Heart attack.· Blood clot.If any of these symptoms accord to the patient he should
stop taking the drug ant go to physician to diagnose his case. Drug
interactions. There is a lot of drug interaction for this specific drug like
300+I will just give some examples for illustration purposes ·
Caffeine.·
Cafatine PB·
Cafergot. ·
cafetrate.·
carbex.